Numerous studies have shown that vitamin D deficiency is very common in modern societies
and is perceived as an important risk factor in the development of insulin resistance and …

Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin
resistance and insulin secretion impairment. These disorders, if not intervened, will …

In both type 1 and type 2 diabetes, the late diabetic complications in nerve, vascular
endothelium, and kidney arise from chronic elevations of glucose and possibly other …

The condition of oxidative stress arises when oxidant production exceeds antioxidant activity
in cells and plasma. The overabundance of oxidants is mechanistically connected to the …

Both insulin resistance (type II diabetes) and β-amyloid (Aβ) oligomers are implicated in
Alzheimer's disease (AD). Here, we investigate the role of Aβ oligomer-induced c-Jun N …

Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-
products of metabolism. However, accumulating evidence has revealed that reactive …

Oxidative stress is an acknowledged pathogenetic mechanism in diabetic complications.
Hyperglycemia is a widely known cause of enhanced free radical concentration, whereas …

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is reported commonly in
patients with type 2 diabetes mellitus (DM), which has been suggested as a risk factor for the …

In diabetes (type 1 and type 2), increased flux of free fatty acids and glucose is associated
with increased mitochondrial reactive oxygen species (ROS) production and, as a …

Prolonged exposure of 3T3-L1 adipocytes to micromolar concentrations of H2O2 results in
an impaired response to the acute metabolic effects of insulin. In this study, we further …