Liver zonation–revisiting old questions with new technologies
RP Cunningham, N Porat-Shliom - Frontiers in physiology, 2021 - frontiersin.org
Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …
[图书][B] Agent-based and individual-based modeling: a practical introduction
SF Railsback, V Grimm - 2019 - books.google.com
The essential textbook on agent-based modeling—now fully updated and expanded Agent-
Based and Individual-Based Modeling has become the standard textbook on the subject for …
Based and Individual-Based Modeling has become the standard textbook on the subject for …
The spectrum of mechanism-oriented models and methods for explanations of biological phenomena
Developing and improving mechanism-oriented computational models to better explain
biological phenomena is a dynamic and expanding frontier. As the complexity of targeted …
biological phenomena is a dynamic and expanding frontier. As the complexity of targeted …
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
Acetaminophen (APAP) is one of the most intensively studied compounds that causes
hepatotoxicity in the pericentral region of the liver lobules. However, spatio-temporal …
hepatotoxicity in the pericentral region of the liver lobules. However, spatio-temporal …
Unraveling the effect of intra-and intercellular processes on acetaminophen-induced liver injury
MM Heldring, AH Shaw, JB Beltman - npj Systems Biology and …, 2022 - nature.com
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility
to liver failure varies across individuals and is influenced by factors such as health status …
to liver failure varies across individuals and is influenced by factors such as health status …
[HTML][HTML] Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti …
Acetaminophen (APAP) is a widely used analgesic, but it may cause liver injury
(hepatotoxicity) via oxidative stress that induced by N-acetyl-p-benzoquinone imine (NAPQI) …
(hepatotoxicity) via oxidative stress that induced by N-acetyl-p-benzoquinone imine (NAPQI) …
In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin
In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we
explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models …
explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models …
Improved protective effects of American ginseng berry against acetaminophen-induced liver toxicity through TNF-α-mediated caspase-3/-8/-9 signaling pathways
XY Xu, Z Wang, S Ren, J Leng, J Hu, Z Liu, C Chen… - Phytomedicine, 2018 - Elsevier
Background Similar to the leaves of P. Quinquefolius, American ginseng berry (AGB) is
another important part of P. Quinquefolius with alternative therapeutic potential. The liver …
another important part of P. Quinquefolius with alternative therapeutic potential. The liver …
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms
AK Smith, GEP Ropella, MR McGill… - PLoS computational …, 2020 - journals.plos.org
Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced
liver injury often assume that the biomarker is released passively from dying cells. However …
liver injury often assume that the biomarker is released passively from dying cells. However …
Mechanistic systems modeling to improve understanding and prediction of cardiotoxicity caused by targeted cancer therapeutics
JV Shim, B Chun, JGC Van Hasselt… - Frontiers in …, 2017 - frontiersin.org
Tyrosine kinase inhibitors (TKIs) are highly potent cancer therapeutics that have been linked
with serious cardiotoxicity, including left ventricular dysfunction, heart failure, and QT …
with serious cardiotoxicity, including left ventricular dysfunction, heart failure, and QT …