Abstract System lupus erythematosus (SLE) is a chronic autoimmune disorder affecting
multiple organs, and persistent disease activity is associated with increased morbidity and …

Although anti-C1q autoantibodies have been described more than four decades ago a
constant stream of papers describing clinical associations or functional consequences …

The accumulation of DNA and nuclear components in blood and their recognition by
autoantibodies play a central role in the pathophysiology of systemic lupus erythematosus …

Loss of B cell tolerance is central to autoimmune diseases such as systemic lupus
erythematosus (SLE). As such, the mechanisms involved in B cell development, maturation …

Profiling the autoantibody repertoire with large antigen collections is emerging as a powerful
tool for the identification of biomarkers for autoimmune diseases. Here, a systematic and …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a broad
spectrum of clinical manifestations. The proposed pathophysiological hypotheses of SLE are …

The complement system has long been known for its role in combating infections. More
recently the complement system is becoming increasingly appreciated for its role in …

Autoantibodies are a key component for the diagnosis, prognosis and monitoring of various
diseases. In order to discover novel autoantibody targets, highly multiplexed assays based …

Objectives The molecular targets of the vast majority of autoantibodies in systemic lupus
erythematosus (SLE) are unknown. We set out to identify novel autoantibodies in SLE to …

Innate immune receptors sense nucleic acids derived from viral pathogens or self-
constituents and initiate an immune response, which involves, among other things, the …