The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole‐rat biology
R Buffenstein, V Amoroso, B Andziak… - Biological …, 2022 - Wiley Online Library
The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a
century. It has also generated considerable biomedical interest not only because of its …
century. It has also generated considerable biomedical interest not only because of its …
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN
A Monteil, NC Guérineau, A Gil-Nagel… - Physiological …, 2024 - journals.physiology.org
Cell excitability and its modulation by hormones and neurotransmitters involve the concerted
action of a large repertoire of membrane proteins, especially ion channels. Unique …
action of a large repertoire of membrane proteins, especially ion channels. Unique …
Persistent nociceptor hyperactivity as a painful evolutionary adaptation
Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …
Structural insights into electrophile irritant sensing by the human TRPA1 channel
Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca 2+-permeable
cation channel that serves as one of the primary sensors of environmental irritants and …
cation channel that serves as one of the primary sensors of environmental irritants and …
Early origin of sweet perception in the songbird radiation
Early events in the evolutionary history of a clade can shape the sensory systems of
descendant lineages. Although the avian ancestor may not have had a sweet receptor, the …
descendant lineages. Although the avian ancestor may not have had a sweet receptor, the …
Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels
F Ullrich, S Blin, K Lazarow, T Daubitz, JP von Kries… - Elife, 2019 - elifesciences.org
Acid-sensing ion channels have important functions in physiology and pathology, but the
molecular composition of acid-activated chloride channels had remained unclear. We now …
molecular composition of acid-activated chloride channels had remained unclear. We now …
Surprisingly long survival of premature conclusions about naked mole‐rat biology
Naked mole‐rats express many unusual traits for such a small rodent. Their morphology,
social behaviour, physiology, and ageing have been well studied over the past half‐century …
social behaviour, physiology, and ageing have been well studied over the past half‐century …
A connectomics-based taxonomy of mammals
Mammalian taxonomies are conventionally defined by morphological traits and genetics.
How species differ in terms of neural circuits and whether inter-species differences in neural …
How species differ in terms of neural circuits and whether inter-species differences in neural …
The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium
HC Chua, M Wulf, C Weidling, LP Rasmussen… - Science …, 2020 - science.org
The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …
African naked mole-rats demonstrate extreme tolerance to hypoxia and hypercapnia
Naked mole-rats are extremely tolerant to low concentrations of oxygen (hypoxia) and high
concentrations of carbon dioxide (hypercapnia), which is consistent with the environment …
concentrations of carbon dioxide (hypercapnia), which is consistent with the environment …