The mechanisms behind the Warburg effect in mammalian cells, as well as for the similar
Crabtree effect in the yeast Saccharomyces cerevisiae, are still a matter of debate: why do …

A systematic and powerful knowledge‐based framework exists for improving the activity and
stability of chemical catalysts and for empowering the commercialization of respective …

A dynamic model of glucose overflow metabolism in batch and fed‐batch cultivations of
Escherichia coli W3110 under fully aerobic conditions is presented. Simulation based on the …

With reaction timescales equal to or shorter than the circulation time, the ideal mixing
assumption typically does not hold for large scale bioreactors. As a consequence large …

A biochemically structured model for the aerobic growth of Saccharomyces cerevisiae on
glucose and ethanol is presented. The model focuses on the pyruvate and acetaldehyde …

Building on the recent revolution in molecular biology, enabling a wealth of bio-product
innovations made from renewable feedstocks, the biotechnology field is in a transition phase …

The inhibitory impacts of the bioconversion of l-phenylalanine (l-Phe) to 2-phenylethanol
(PEA), a very important natural aroma compound, on the metabolism of Saccharomyces …

Terpenes have various applications as fragrances, cosmetics and fuels. One of the most
prominent examples is the sesquiterpene farnesene, which can be used as diesel substitute …

For the first time a laboratory‐scale two‐compartment system was used to investigate the
effects of pH fluctuations consequent to large scales of operation on microorganisms. pH …

A new set of mathematical equations describing overflow metabolism and acetate
accumulation in E. coli cultivation is presented. The model is a significant improvement of …