Caffeine is the globally consumed psychoactive substance and the drug of choice for the
treatment of apnea of prematurity (AOP), but its therapeutic effects are highly variable among …

Background Considerable interindividual variability for the pharmacokinetics of caffeine in
preterm infants has been demonstrated, emphasizing the importance of personalized …

High-risk preterm infants are affected by a higher incidence of cognitive developmental
deficits due to the unavoidable risk factor of oxygen toxicity. Caffeine is known to have a …

A cobalt-based metal–organic framework and graphene oxide were combined to prepare a
new nanocomposite for extracting of caffeine from exhaled breath condensate (EBC) …

Objective We conducted a systematic review to investigate electroencephalography (EEG)
changes during periods of acute respiratory events such as apnoea and the effect of …

Current standard-dose caffeine therapy results in significant intersubject variability. The aims
of this study were to develop and evaluate population pharmacokinetic (PPK) models of …

Ventilatory drive is modulated by a variety of neurochemical inputs that converge on
spatially oriented clusters of cells within the brainstem. This regulation is required to …

Abstract Patients in the Neonatal Intensive Care Unit (NICU) have high mortality and
morbidity rates due to their low birth weight or being preterm. Due to their vulnerability …

We have some questions about this study. First, why did the authors use the third edition of
the Bayley Scales of Infant and Toddler Development (BSID-III) and the Parent Report of …

Apnea of prematurity (AOP) is onc of the common diseases in preterm infants. The main
cause of AOP is immature development of the respiratory control center. If AOP is not treated …