The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …

The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family
that is abnormally activated in many epithelial tumors. Receptor activation leads to …

Abstract Signal Transducers and Activators of Transcription (STATs) are a family of
cytoplasmic proteins with roles as signal messengers and transcription factors that …

Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that
binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting …

The epidermal growth factor receptor (ErbB1 or EGFR) has been found to be altered in a
variety of human cancers. A number of agents targeting these receptors, including specific …

The epidermal growth factor receptor (EGFR) is expressed in a wide variety of solid tumours.
It has been demonstrated that the EGFR-associated signaling pathway plays an important …

Transactivation of the epidermal growth factor receptor (EGFR) represents the paradigm for
cross-talk between G protein-coupled receptors (GPCRs) and receptor tyrosine kinase …

Growth factor receptors and their ligands not only regulate normal cell processes but have
been also identified as key regulators of human cancer formation. The epidermal growth …

The majority of patients with head and neck squamous cell carcinoma (HNSCC) present
with advanced-stage disease. The current standard of care is surgery followed by adjuvant …

Purpose: Epithelial cell adhesion molecule (Ep-CAM) is a tumor-associated antigen
overexpressed in many solid tumors but shows limited expression in normal epithelial …