Simple Summary Glioblastoma is the most common brain cancer, and prognosis remains
dismal. Continued efforts to find better treatments have shown the promise of …

Chimeric antigen receptor (CAR) T cell therapy stands as a transformative advancement in
immunotherapy, triumphing against hematological malignancies and, increasingly …

Background This study aimed to validate whether infusion of GD2-specific fourth-generation
safety-designed chimeric antigen receptor (4SCAR)-T cells is safe and whether CAR-T cells …

Simple Summary Glycosylation is one of the most pivotal post-translational modifications on
all types of biomolecules for the formation of glycoproteins, glycolipids, and glycoRNAs in a …

Chimeric antigen receptor T cells (CAR-T) therapy has shown great potential in tumor
treatment. However, many factors impair the efficacy of CAR-T therapy, such as antigenic …

Background Glioblastoma (GBM) is recognized as among the most aggressive forms of
brain tumor. Patients typically present with a five-year survival rate of less than 6% with …

Glioblastoma is an aggressive primary brain tumor that has seen few advances in treatments
for over 20 years. In response to this desperate clinical need, multiple immunotherapy …

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Glioblastoma (GBM) is a highly aggressive primary brain tumor that is largely refractory to
treatment and, therefore, invariably relapses. GBM patients have a median overall survival of …

Simple Summary Chimeric antigen receptor (CAR) cell-based therapy is a promising
treatment approach for glioblastoma, a fatal brain cancer with limited treatment options …