Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Subarachnoid haemorrhage (SAH) is the third most common subtype of stroke. Incidence
has decreased over past decades, possibly in part related to lifestyle changes such as …

Background There is insufficient evidence to guide ventilatory targets in acute brain injury
(ABI). Recent studies have shown associations between mechanical power (MP) and …

BACKGROUND: Optimal blood pressure (BP) management during endovascular stroke
treatment is not well established. We studied whether an individualized approach for …

Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical
ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung …

BACKGROUND: Patients with stroke receiving invasive mechanical ventilation (IMV) and
tracheostomy incur intense treatment and long hospitalizations. We aimed to evaluate US …

Ischemic stroke (IS) is a common and severe condition that requires intensive care unit (ICU)
admission, with high mortality and variable prognosis. Accurate and reliable predictive tools …

Liberating patients with severe traumatic brain injury (TBI) from mechanical ventilation is
often a challenging task. These patients frequently require prolonged ventilation and have …

Introduction There is little consensus and high heterogeneity on the optimal set of relevant
clinical outcomes in research studies regarding extubation in neurocritical care patients with …

Abstract Background Randomised controlled trials (RCTs) aim to estimate the causal effect
of one or more interventions relative to a control. One type of outcome that can be of interest …