Generation, transformation, and utilization of organic molecules in support of cellular
differentiation, growth, and maintenance are basic tenets that define life. In eukaryotes …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

It has been assumed, based largely on morphologic evidence, that human pluripotent stem
cells (hPSCs) contain underdeveloped, bioenergetically inactive mitochondria. In contrast …

Limb remote ischemic preconditioning (RIPC) is an effective means of protection against
ischemia/reperfusion (IR)–induced injury to multiple organs. Many studies are focused on …

Mitochondria are essential organelles that act as metabolic hubs and signaling platforms
within the cell. Numerous mitochondrial functions, including energy metabolism, lipid …

The metabolic and energy state of the organism depends largely on the availability of
substrates, such as glucose for ATP production, necessary for maintaining physiological …

Microglia play a crucial role in immune responses, including inflammation. Diet-induced
obesity (DIO) triggers microglia activation and hypothalamic inflammation as early as 3 days …

Highlights What are the main findings? Hypothesis: Redox, bioenergetic and temperature
regulation is critical in maintaining cellular circadian rhythms; wakefulness is mainly …

Uncoupling protein 1 (UCP1), is a unique mitochondrial membranous protein devoted to
adaptive thermogenesis, a specialized function performed by brown adipocytes. Whereas …