Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

Circadian rhythms, which have long been known to play crucial roles in physiology, are
emerging as important regulators of specific immune functions. Circadian oscillations of …

Background The up-regulation of P-selectin in endothelial cells and platelets contributes to
the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle …

Blood polymorphonuclear neutrophils provide immune protection against pathogens, but
may also promote tissue injury in inflammatory diseases,. Although neutrophils are generally …

Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of …

Abstract Treatment of sickle cell disease (SCD) is hampered by incomplete understanding of
pathways linking hemolysis to vaso-occlusion. We investigated these pathways in …

Early diagnosis, treatment, and prevention of a vaso‐occlusive crisis (VOC) are critical to the
management of patients with sickle cell disease. It is essential to differentiate between VOC …

Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell
disease. Symptomatic management and prevention of these events using the fetal …

Sickle-cell disease is one of the most common severe monogenic disorders in the world.
Haemoglobin polymerisation, leading to erythrocyte rigidity and vaso-occlusion, is central to …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …