[HTML][HTML] Human olfactory receptors: novel cellular functions outside of the nose

D Maßberg, H Hatt - Physiological reviews, 2018 - journals.physiology.org
Olfactory receptors (ORs) are not exclusively expressed in the olfactory sensory neurons;
they are also observed outside of the olfactory system in all other human tissues tested to …

Progress in the development of olfactory-based bioelectronic chemosensors

JW Cave, J Kenneth, AN Mitropoulos - Biosensors and Bioelectronics, 2019 - Elsevier
Artificial chemosensory devices have a wide range of applications in industry, security, and
medicine. The development of these devices has been inspired by the speed, sensitivity …

Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons

K Monahan, I Schieren, J Cheung, A Mumbey-Wafula… - Elife, 2017 - elifesciences.org
The monogenic and monoallelic expression of only one out of> 1000 mouse olfactory
receptor (ORs) genes requires the formation of large heterochromatic chromatin domains …

Single olfactory receptors set odor detection thresholds

A Dewan, A Cichy, J Zhang, K Miguel… - Nature …, 2018 - nature.com
In many species, survival depends on olfaction, yet the mechanisms that underlie olfactory
sensitivity are not well understood. Here we examine how a conserved subset of olfactory …

A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans

LR Saraiva, F Riveros-McKay, M Mezzavilla… - Science …, 2019 - science.org
The mammalian olfactory system displays species-specific adaptations to different
ecological niches. To investigate the evolutionary dynamics of olfactory sensory neuron …

Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

X Ibarra-Soria, TS Nakahara, J Lilue, Y Jiang… - Elife, 2017 - elifesciences.org
The mouse olfactory sensory neuron (OSN) repertoire is composed of 10 million cells and
each expresses one olfactory receptor (OR) gene from a pool of over 1000. Thus, the nose is …

[HTML][HTML] Olfactory stimulation regulates the birth of neurons that express specific odorant receptors

CJ van der Linden, P Gupta, AI Bhuiya, KR Riddick… - Cell reports, 2020 - cell.com
In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to
replace damaged OSNs. During differentiation, each OSN precursor" chooses," out of …

Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line

T Ieki, Y Yamanaka, K Yoshikawa - Plos one, 2022 - journals.plos.org
Humans use a family of more than 400 olfactory receptors (ORs) to detect odorants.
However, deorphanization of ORs is a critical issue because the functional properties of …

[HTML][HTML] In mice, discrete odors can selectively promote the neurogenesis of sensory neuron subtypes that they stimulate

K Hossain, M Smith, SW Santoro - bioRxiv, 2024 - ncbi.nlm.nih.gov
In mammals, olfactory sensory neurons (OSNs) are born throughout life, presumably solely
to replace neurons lost via turnover or injury. This assumption follows from the hypothesis …

A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo

M Omura, Y Takabatake, E Lempert… - Science …, 2022 - science.org
The molecular basis for odor perception in humans remains enigmatic because of the
difficulty in studying odorant receptors (ORs) outside their native environment. Efforts toward …