The roles of androgens in humans: biology, metabolic regulation and health

M Alemany - International journal of molecular sciences, 2022 - mdpi.com
Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Gender, sex steroid hormones, and Alzheimer's disease

RS Vest, CJ Pike - Hormones and behavior, 2013 - Elsevier
This article is part of a Special Issue" Hormones & Neurotrauma". Age-related loss of sex
steroid hormones is a established risk factor for the development of Alzheimer's disease …

Drug development for Alzheimer's disease: microglia induced neuroinflammation as a target?

Y Dong, X Li, J Cheng, L Hou - International Journal of Molecular …, 2019 - mdpi.com
Alzheimer's disease (AD) is one of the most common causes of dementia. Its pathogenesis
is characterized by the aggregation of the amyloid-β (Aβ) protein in senile plaques and the …

[HTML][HTML] Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

SI Mota, RO Costa, IL Ferreira, I Santana… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Oxidative stress and endoplasmic reticulum (ER) stress have been associated with
Alzheimer's disease (AD) progression. In this study we analyzed whether oxidative stress …

Intracellular calcium dysregulation: implications for Alzheimer's disease

S Magi, P Castaldo, ML Macrì… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive
neuronal loss. AD is associated with aberrant processing of the amyloid precursor protein …

Metabolic impact of estrogen signalling through ERalpha and ERbeta

A Foryst-Ludwig, U Kintscher - The Journal of steroid biochemistry and …, 2010 - Elsevier
Estrogens, acting on both estrogen receptors alpha (ERalpha) and beta (ERbeta) are
recognized as important regulators of glucose homeostasis and lipid metabolism. ERs …

Health issues for menopausal women: the top 11 conditions have common solutions

GM Van Dijk, M Kavousi, J Troup, OH Franco - Maturitas, 2015 - Elsevier
Multiple health issues affect women throughout the life course differently from men, or do not
affect men at all. Although attention to women's health is important in all stages in life, health …

Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease

M Gomez Ravetti, OA Rosso, R Berretta, P Moscato - PloS one, 2010 - journals.plos.org
Background Alzheimer's disease (AD) is characterized by a neurodegenerative progression
that alters cognition. On a phenotypical level, cognition is evaluated by means of the …

Sex difference in spinal muscular atrophy patients–are males more vulnerable?

J Sun, MA Harrington, B Porter… - Journal of …, 2023 - journals.sagepub.com
Background: Sex is a significant risk factor in many neurodegenerative disorders. A better
understanding of the molecular mechanisms behind sex differences could help develop …

Estrogen-dependent hippocampal wiring as a risk factor for age-related dementia in women

G Torromino, A Maggi, E De Leonibus - Progress in Neurobiology, 2021 - Elsevier
Women are more prone than men to develop age-related dementia, such as Alzheimer's
disease (AD). This has been linked to the marked decrease in circulating estrogens during …