Cognitively driven pupil modulations reflect certain underlying brain functions. What do
these reflections tell us? Here, we review findings that have identified key roles for three …

Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

Through a widespread efferent projection system, the locus coeruleus–noradrenergic
system supplies norepinephrine throughout the central nervous system. Initial studies …

The principal neurons of the arousal and sleep circuits are comprised by glutamate and
GABA neurons, which are distributed within the reticular core of the brain and, through local …

The locus coeruleus (LC) is the major noradrenergic nucleus of the brain, giving rise to
fibres innervating extensive areas throughout the neuraxis. Recent advances in …

The central noradrenergic neurone, like the peripheral sympathetic neurone, is
characterized by a diffusely arborizing terminal axonal network. The central neurones …

The locus coeruleus-noradrenergic system supplies norepinephrine throughout the central
nervous system. State-dependent neuronal discharge activity of locus coeruleus …

During various states of vigilance, brain oscillations are grouped together through reciprocal
connections between the neocortex and thalamus. The coherent activity in corticothalamic …