Bone grafting is a commonly performed surgical procedure to augment bone regeneration in
a variety of cases in orthopaedic and maxillofacial surgery. Autologous bone graft remains to …

Inflammation is an immediate response that plays a critical role in healing after fracture or
injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in …

Nonunion and large bone defects present a therapeutic challenge to the surgeon and are
often associated with significant morbidity. These defects are expensive to both the health …

Bone healing is a multifarious process involving mesenchymal stem cells, osteoprogenitor
cells, macrophages, osteoblasts and-clasts, and chondrocytes to restore the osseous tissue …

The management of bone defects caused by trauma and nonunion continues to represent a
substantial clinical challenge in the management of orthopaedic trauma patients. A variety of …

Background The 'reamer-irrigator-aspirator'(RIA) is an innovation developed to reduce fat
embolism (FE) and thermal necrosis (TN) that can occur during reaming/nailing of long-bone …

Segmental bone defect management is among the most demanding issues in orthopaedics
and there is a great medical need for establishing an appropriate treatment option. Tissue …

Purpose The purpose of this study was to review experimental and clinical experiences
about the use of an induced membrane to address critical bone size defect of the limbs …

Orthopedic injuries are common and a source of much misery and economic stress. Several
relevant tissues, such as cartilage, meniscus, and intra-articular ligaments, do not heal. And …

Objectives Reconstruction of long segmental bone defects is demanding for patients and
surgeons, and associated with long-term treatment periods and substantial complication …