A balancing act: The role of pro‐and anti‐stress peptides within the central amygdala in anxiety and alcohol use disorders

LC Walker - Journal of neurochemistry, 2021 - Wiley Online Library
The central nucleus of the amygdala (CeA) is widely implicated as a structure that integrates
both appetitive and aversive stimuli. While intrinsic CeA microcircuits primarily consist of …

Cocaine and amphetamine regulated transcript (CART) and the stress response

EO Koylu, B Balkan, MJ Kuhar, S Pogun - Peptides, 2006 - Elsevier
CART is expressed abundantly in the hypothalamic paraventricular nucleus and locus
coeruleus, major corticotropin releasing factor (CRF) and noradrenaline sources …

Resting state functional connectivity of the lateral and medial hypothalamus in cocaine dependence: an exploratory study

S Zhang, W Wang, S Zhornitsky, CR Li - Frontiers in Psychiatry, 2018 - frontiersin.org
The role of dopamine in cocaine misuse has been extensively documented for the
mesocorticolimbic circuit. Preclinical work from earlier lesion studies to recent …

Cocaine-and amphetamine-regulated transcript peptide plays a role in the manifestation of depression: social isolation and olfactory bulbectomy models reveal …

MP Dandekar, PS Singru, DM Kokare… - …, 2009 - nature.com
We investigated the effect of cocaine-and amphetamine-regulated transcript (CART) peptide
on depression-like behavior in socially isolated and olfactory bulbectomized (OBX) rats …

Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking

LC Walker, LJ Hand, B Letherby, KL Huckstep… - …, 2021 - nature.com
The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating
alcohol and stress interactions. However, the exact neuronal populations that govern this …

Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala

RG Hunter, R Bellani, E Bloss, A Costa, RD Romeo… - Brain research, 2007 - Elsevier
CART (Cocaine-Amphetamine-Regulated Transcript) has been shown to be regulated by
corticosteroids in the hypothalamus, but its regulation by corticosteroids and stress has not …

Nicotinic cholinergic system in the hypothalamus modulates the activity of the hypothalamic neuropeptides during the stress response

B Balkan, S Pogun - Current Neuropharmacology, 2018 - ingentaconnect.com
Background: The hypothalamus harbors high levels of cholinergic neurons and axon
terminals. Nicotinic acetylcholine receptors, which play an important role in cholinergic …

Peptidergic modulation of motor neuron output via CART signaling at C bouton synapses

PE Eleftheriadis, K Pothakos… - Proceedings of the …, 2023 - National Acad Sciences
The intensity of muscle contraction, and therefore movement vigor, needs to be adaptable to
enable complex motor behaviors. This can be achieved by adjusting the properties of motor …

Differences in the dopaminergic reward system in rats that passively and actively behave in the Porsolt test

A Wisłowska-Stanek, A Płaźnik, K Kołosowska… - Behavioural Brain …, 2019 - Elsevier
The aim of the study was to assess appetitive responses and central dopaminergic
neurotransmission in passive and active rats divided according to their immobility time in the …

Forced swim stress elicits region-specific changes in CART expression in the stress axis and stress regulatory brain areas

B Balkan, A Keser, O Gozen, EO Koylu, T Dagci… - Brain research, 2012 - Elsevier
CART mRNA and peptides are highly expressed in the anatomical structures composing the
hypothalamo-pituitary-adrenal (HPA) axis and sympatho-adrenal system. Anatomical and …