Background Depression is a recurrent illness with high rates of chronicity, treatment‐
resistance and significant economic impact. There is evidence in the literature that S …

Background Research suggests that depressive disorders exist on a continuum, with
subthreshold symptoms causing considerable population burden and increasing individual …

ABSTRACT A library of engineered promoters of various strengths is a useful genetic tool
that enables the fine-tuning and precise control of gene expression across a continuum of …

This narrative review was conducted using searches of the PubMed/Medline and Google
Scholar databases from inception to November 2019. Clinical trials and relevant articles …

Methylation reactions linked to homocysteine in the one-carbon metabolism are increasingly
elicited in Alzheimer's disease, although the association of hyperhomocysteinemia and of …

Updated for its Seventh Edition, Principles of Ambulatory Medicine is the definitive reference
for all clinicians caring for adult ambulatory patients. It provides in-depth coverage of the …

The polyamine pathway has an essential role in many cellular functions and has been
implicated in several pathological conditions. Accumulating evidence suggests that the …

Recent data show that colon cancer cells selectively overexpress cystathionine-β-synthase
(CBS), which produces hydrogen sulfide (H 2 S), to maintain cellular bioenergetics, support …

BACKGROUND: In 2001, the Canadian Psychiatric Association and the Canadian Network
for Mood and Anxiety Treatments (CANMAT) partnered to produce evidence-based clinical …

Objectives Approximately one-third of major depressive disorder (MDD) patients do not
respond to standard antidepressants and develop treatment-resistant depression (TRD). We …