Post-translational modifications of connexins play an important role in the regulation of gap
junction and hemichannel permeability. The prerequisite for the formation of functional gap …

Connexins are integral membrane building blocks that form gap junctions, enabling direct
cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells …

Gap junction channels mediate intercellular signalling that is crucial in tissue development,
homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To …

Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a
critical second messenger involved in numerous biological activities through extensive …

COVID-19 public health protocols have altered children's daily routines, limiting their
physical activity opportunities. The purpose of this study was to examine how the COVID-19 …

Astrocytic gap junctional coupling is a major element in neuron–glia interaction. There is
strong evidence that impaired coupling is involved in neurological disorders. Reduced …

Ubiquitously expressed connexins are tetra-spanning transmembrane proteins that form
intercellular gap junction channels or cell surface hemichannels. Connexins share similar …

Familial cerebral cavernous malformations type III (fCCM3) is a disease of the
cerebrovascular system caused by loss-of-function mutations in ccm3 that result in dilated …

Melanoma is the most aggressive skin malignancy with increasing incidence worldwide.
Pannexin1 (PANX1), a member of the pannexin family of channel-forming glycoproteins …

Electrical conduction in cardiac tissue is usually considered to be primarily facilitated by gap
junctions, providing a pathway between the intracellular spaces of neighboring cells …