The development of interdisciplinary biomedical engineering brings significant
breakthroughs to the field of cartilage regeneration. However, cartilage defects are …

BACKGROUND: The use of bone marrow concentrate (BMC) for treatment of
musculoskeletal disorders has become increasingly popular over the last several years, as …

Hypertrophic differentiation is not only the terminal process of endochondral ossification in
the growth plate but is also an important pathological change in osteoarthritic cartilage …

Objective: Iron overload is common in elderly people which is associated with an increased
prevalence of osteoarthritis (OA), but the exact role of iron in the development of OA has not …

Osteoarthritis (OA), the most common aging-related joint disease, is caused by an
imbalance between extracellular matrix synthesis and degradation. Here, we discover that …

Osteoarthritis (OA) is a common joint disease that takes joint degeneration or aging as its
pathological basis, and joint swelling, pain or dysfunction as its main clinical manifestations …

The WW domain-containing protein 2 (Wwp2) gene, the host gene of miR-140, codes for the
Wwp2 protein, which is an HECT-type E3 ubiquitin ligases abundantly expressed in articular …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic,
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …

Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage
lesions is a public health challenge to prevent long-term degradation and the occurrence of …