Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Genome sequencing and gene expression analyses of prostate tumours have highlighted
the potential importance of genetic and epigenetic changes observed in WNT signalling …

Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of
androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone …

Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …

Oncogenic targets acting in both tumor cells and tumor stromal cells may offer special
therapeutic appeal. Interrogation of the Oncomine database revealed that 52 of 53 human …

The WNT signaling cascade is integral in numerous biological processes including
embryonic development, cell cycle regulation, inflammation, and cancer. Hyperactivation of …

Patients with advanced prostate cancer (PCa) frequently develop skeletal metastases that
are associated with fractures, disability, and increased mortality. Within the bone metastatic …

Mediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming,
are differentially regulated by androgen signaling, but both kinases are upregulated in …

Wnt ligands are secreted signaling proteins that display a wide range of biological effects.
They play key roles in stimulating Wnt signaling pathways to facilitate processes such as …

Wnt signaling occurs through evolutionarily conserved pathways that affect cellular
proliferation and fate decisions during development and tissue maintenance. Alterations in …