The endocannabinoid system (ECS) has been shown to be of great importance in the
regulation of numerous physiological and pathological processes. To date, two Class A G …

Abstract Cannabinoid receptors 1 and 2 (CB 1 and CB 2) are implicated in a range of
physiological processes and have gained attention as promising therapeutic targets for a …

The genesis of designing bivalent or bitopic molecules that engender unique
pharmacological properties began with Portoghese's work directed toward opioid receptors …

Pharmacological probes for the melanocortin receptors have been utilized for studying
various disease states including cancer, sexual function disorders, Alzheimer's disease …

Single chemical entities with potential to simultaneously interact with two binding sites are
emerging strategies in medicinal chemistry. We have designed, synthesized and functionally …

Bivalent ligands, ie, molecules having two ligands covalently connected by a linker, have
been gathering attention since the first description of their pharmacological potential in the …

Alterations in olfactory functions are proposed as possible early biomarkers of
neurodegenerative diseases. Parkinson's and Alzheimer's diseases manifest olfactory …

Bivalent ligands bridging two G-protein-coupled receptors (GPCRs) provide valuable
pharmacological tools to target oligomers. The success of therapeutically targeting the …

Since the identification of the endocannabinoid system, two G protein‐coupled receptors
(GPCRs) of this complex system were identified and characterized: cannabinoid receptors …

Bivalent ligands targeting putative melanocortin receptor dimers have been developed and
characterized in vitro; however, studies of their functional in vivo effects have been limited …