Glycogen synthase kinase-3β (GSK-3β) is a conserved serine/threonine kinase that
participates in the transmission of multiple signaling pathways and plays an important role in …

The present review article strives to compile the latest synthetic approaches for the synthesis
of triazolothiadiazine and its derivatives, along with their diverse pharmacological activities …

The target mono-and bis-(6-pyrazolyltriazolo-thiadiazine) derivatives 4a-c and 6a-d were
synthesized using a straightforward protocol via reaction of 3-bromoacetylpyrazole 2 with 4 …

This review article examines the synthetic pathways for triazolothiadiazine derivatives, such
as triazolo [3, 4-b] thiadiazines, triazolo [5, 1-b] thiadiazines, and triazolo [4, 3-c] …

Abstract Novel 2‐Amino‐4H‐1, 3, 4‐thiadiazine‐5‐(6H)‐one derivatives 3–6 were designed,
synthesized, and assessed for their anticancer effects on MCF‐7 and A549 cell lines. The …

A highly regioselective inverse electron-demand aza-Diels–Alder reaction of α, β-
unsaturated thioesters with 1, 2-diaza-1, 3-dienes generated in situ from α-halogeno …

A new series of 1, 3, 4-thiadiazin-3-ium bromide derivatives 9a–g were prepared as a six-
member ring by interactions between 4-substituted thiosemicarbazides 8a–e and α-halo …

A facile one-pot three component domino protocol has been successfully developed for the
combinatorial synthesis of novel Schiff bases of 3-(2-(6-amino-7H-[1, 2, 4]-triazolo [3, 4-b][1 …

Materials and methods. The synthesis of the target products of chemical transformation was
successfully implemented by the step-by-step use of well-known methods of organic …

Materials and methods. The chemical part of the work involved the step-by-step creation of
target reaction products in the form of 3-(ethylthio)-9-methyl-6-(alkylthio) pyrazolo [1, 5-d][1 …