Malic acid derived from fossil resources is currently applied in the food and beverage
industries with a medium global production capacity. However, in the transition from a fossil …

Organic acids, which are chemically synthesized, are also natural intermediates in the
metabolic pathways of microorganisms, among which the tricarboxylic acid (TCA) cycle is …

Over the last few decades, increasing concerns regarding fossil fuel depletion and
excessive CO2 emissions have led to extensive fundamental studies and industrial trials …

Background Advanced DNA synthesis, biosensor assembly, and genetic circuit
development in synthetic biology and metabolic engineering have reinforced the application …

Malic acid, a four-carbon dicarboxylic acid, is widely used in the food, chemical and medical
industries. As an intermediate of the TCA cycle, malic acid is one of the most promising …

Abstract l-Malic acid has many uses in food, beverage, pharmaceutical, chemical and
medical industries. It can be produced by one-step fermentation, enzymatic transformation of …

Isolates of Aspergillus species are able to produce a large number of secondary
metabolites. The profiles of biosynthetic families of secondary metabolites are species …

Filamentous fungi from the genus Aspergillus are of high importance for biobased organic
acid production. So far, a number of Aspergillus strains belonging to phylogenetically …

The tricarboxylic acid (TCA) cycle has been used for decades in the microbial production of
chemicals such as citrate, L-glutamate, and succinate. Maximizing yield is key for cost …

Polymalic acid (PMA) production by Aureobasidium pullulans ZX-10 from soybean hull
hydrolysate supplemented with corn steep liquor (CSL) gave a malic acid yield of∼ 0.4 g/g …