Nutritional immunity: the battle for nutrient metals at the host–pathogen interface

CC Murdoch, EP Skaar - Nature Reviews Microbiology, 2022 - nature.com
Trace metals are essential micronutrients required for survival across all kingdoms of life.
From bacteria to animals, metals have critical roles as both structural and catalytic cofactors …

An overview of siderophore biosynthesis among fluorescent Pseudomonads and new insights into their complex cellular organization

IJ Schalk, C Rigouin, J Godet - Environmental Microbiology, 2020 - Wiley Online Library
Siderophores are iron‐chelating molecules produced by bacteria to access iron, a key
nutrient. These compounds have highly diverse chemical structures, with various chelating …

Permeability barrier of Gram-negative cell envelopes and approaches to bypass it

HI Zgurskaya, CA López… - ACS infectious diseases, 2015 - ACS Publications
Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have
acquired multidrug resistance and cause infections that are effectively untreatable present a …

A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition

J Lin, W Zhang, J Cheng, X Yang, K Zhu… - Nature …, 2017 - nature.com
Iron sequestration by host proteins contributes to the defence against bacterial pathogens,
which need iron for their metabolism and virulence. A Pseudomonas aeruginosa mutant …

The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

L Moynié, S Milenkovic, GLA Mislin, V Gasser… - Nature …, 2019 - nature.com
Bacteria use small molecules called siderophores to scavenge iron. Siderophore-Fe3+
complexes are recognised by outer-membrane transporters and imported into the periplasm …

Pseudomonas aeruginosa zinc uptake in chelating environment is primarily mediated by the metallophore pseudopaline

S Lhospice, NO Gomez, L Ouerdane, C Brutesco… - Scientific reports, 2017 - nature.com
Metal uptake is vital for all living organisms. In metal scarce conditions a common bacterial
strategy consists in the biosynthesis of metallophores, their export in the extracellular …

The human innate immune protein calprotectin induces iron starvation responses in Pseudomonas aeruginosa

EM Zygiel, CE Nelson, LK Brewer… - Journal of Biological …, 2019 - ASBMB
Most microbial pathogens have a metabolic iron requirement, necessitating the acquisition
of this nutrient in the host. In response to pathogen invasion, the human host limits iron …

Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH

G Ganne, K Brillet, B Basta, B Roche… - ACS chemical …, 2017 - ACS Publications
Siderophores are iron chelators produced by bacteria to access iron, an essential nutriment.
Pyoverdine (PVDI), the major siderophore produced by Pseudomonas aeruginosa PAO1 …

Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens

V Vollenweider, K Rehm, C Chepkirui… - eLife, 2024 - elifesciences.org
The global rise of antibiotic resistance calls for new drugs against bacterial pathogens. A
common approach is to search for natural compounds deployed by microbes to inhibit …

Opportunistic use of catecholamine neurotransmitters as siderophores to access iron by Pseudomonas aeruginosa

Q Perraud, L Kuhn, S Fritsch, G Graulier… - Environmental …, 2022 - Wiley Online Library
Iron is an essential nutrient for bacterial growth and the cause of a fierce battle between the
pathogen and host during infection. Bacteria have developed several strategies to access …