[HTML][HTML] Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization

TR Guilarte, AN Rodichkin, JL McGlothan… - Pharmacology & …, 2022 - Elsevier
Abstract Translocator Protein 18 kDa (TSPO), previously named Peripheral Benzodiazepine
Receptor, is a well-validated and widely used biomarker of neuroinflammation to assess …

Oxytocin, dopamine, and opioid interactions underlying pair bonding: highlighting a potential role for microglia

MK Loth, ZR Donaldson - Endocrinology, 2021 - academic.oup.com
Pair bonds represent some of the strongest attachments we form as humans. These
relationships positively modulate health and well-being. Conversely, the loss of a spouse is …

Reactive oxygen species: not omnipresent but important in many locations

M Herb, A Gluschko, M Schramm - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), such as the superoxide anion or hydrogen peroxide, have
been established over decades of research as, on the one hand, important and versatile …

Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers

AM Acanda De La Rocha, NE Berlow, M Fader… - Nature Medicine, 2024 - nature.com
Children with rare, relapsed or refractory cancers often face limited treatment options, and
few predictive biomarkers are available that can enable personalized treatment …

Review detection of Newcastle disease virus

Q Mao, S Ma, PL Schrickel, P Zhao, J Wang… - Frontiers in Veterinary …, 2022 - frontiersin.org
Newcastle disease (ND) is an acute and highly contagious disease caused by the
Newcastle disease virus (NDV) infecting poultry, which has caused great harm to the poultry …

Peroxisomal metabolite and cofactor transport in humans

S Chornyi, L IJlst, CWT van Roermund… - Frontiers in cell and …, 2021 - frontiersin.org
Peroxisomes are membrane-bound organelles involved in many metabolic pathways and
essential for human health. They harbor a large number of enzymes involved in the different …

Microglia as therapeutic target for radiation-induced brain injury

Q Liu, Y Huang, M Duan, Q Yang, B Ren… - International journal of …, 2022 - mdpi.com
Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly
important factor affecting the prognosis of patients with head and neck tumor. With the …

TSPO protein binding partners in bacteria, animals, and plants

C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …

New TSPO crystal structures of mutant and heme-bound forms with altered flexibility, ligand binding, and porphyrin degradation activity

J Liu, C Hiser, F Li, R Hall, RM Garavito… - Biochemistry, 2023 - ACS Publications
The ancient protein TSPO (translocator protein 18kD) is found in all kingdoms and was
originally identified as a binding site of benzodiazepine drugs. Its physiological function …

Mitochondrial translocator protein (TSPO) expression in the brain after whole body gamma irradiation

C Betlazar, RJ Middleton, N Howell, B Storer… - Frontiers in Cell and …, 2021 - frontiersin.org
The brain's early response to low dose ionizing radiation, as may be encountered during
diagnostic procedures and space exploration, is not yet fully characterized. In the brain …