Proteasomes are major sites for protein degradation in eukaryotic cells. The recent
identification of selective proteasome inhibitors has allowed a definition of the roles of the …

Studies on sterol biosynthesis in the yeast, Saccharomyces cerevisiae, and in strains
auxotrophic for the fungal sterol, ergosterol, suggest that sterol plays significant …

We demonstrate that the major in vivo targets of brefeldin A (BFA) in the secretory pathway
of budding yeast are the three members of the Sec7 domain family of ARF exchange factors …

Covalent intermediates between topoisomerase I and DNA can become dead-end
complexes that lead to cell death. Here, the isolation of the gene for an enzyme that can …

Using three different trans dominant mutants of bovine ARF1 affecting GDP exchange or
GTP hydrolysis we demonstrate the central role of ARF1 in controlling vesicular traffic from …

We have studied whether various agents that inhibit purified yeast and mammalian 26 S
proteasome can suppress the breakdown of different classes of proteins in Saccharomyces …

Some Candida albicans isolates from AIDS patients with oropharyngeal candidiasis are
becoming resistant to the azole antifungal agent fluconazole after prolonged treatment with …

Pharmacological agents have proven useful for gaining fundamental insights into the
biology of the Golgi apparatus. This review summarizes pertinent and recent work on the …

It has been proposed that cytoplasmic peptide: N-glycanase (PNGase) may be involved in
the proteasome-dependent quality control machinery used to degrade newly synthesized …

Abstract THE ADP-ribosylation factor ARF is a small GTP-binding protein that is involved in
the transport of vesicles between the endo-plasmic reticulum (ER) and Golgi complex and …