Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-
lowering effects, well-established safety profile, and relatively low cost. While metformin has …

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Metformin is a drug from the biguanide family that is used for decades as the first-line
therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Metformin exerts its plasma glucose-lowering therapeutic effect primarily through inhibition
of hepatic gluconeogenesis. However, the precise molecular mechanism by which …

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Metformin, a cheap and safe biguanide derivative, due to its ability to influence metabolism,
is widely used as a first-line drug for type 2 diabetes (T2DM) treatment. Therefore, the aim of …

Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and
non-cell autonomous processes, leading to several consequences for the organism. To …

Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes
worldwide. Metformin also retards aging in model organisms and reduces the incidence of …

Mitochondrial dysfunction is a hallmark of numerous diseases, including neurodegenerative
disorders, metabolic disorders, and cancer. Mitochondrial transfer, the transfer of …