Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

The development of the central nervous system is highly complex, involving numerous
developmental processes that must take place with high spatial and temporal precision. This …

Rationale: Pain and depression, which tend to occur simultaneously and share some
common neural circuits and neurotransmitters, are highly prevalent complication in patients …

In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and
branching by positively regulating PI3K/PI (3, 4, 5) P 3, but how neurons are able to …

Highlights•Axon guidance is a critical step in neural circuit development.•Recent work
identified novel guidance cues and guidepost cells.•Axon guidance is regulated by …

One class of molecules that are now coming to be recognized as essential for our
understanding of the nervous system are the lysophospholipids. One of the major signaling …

Lysophosphatidic acid (LPA) is a bioactive phospholipid that participates in critical
processes in neural development and adult brain function and is implicated in various …

Neuronal plasma membrane proteins are essential for integrating cell extrinsic and cell
intrinsic signals to orchestrate neuronal differentiation, growth and plasticity in the …

During neural circuit formation, axons need to navigate to their target cells in a complex,
constantly changing environment. Although we most likely have identified most axon …

Abstract Background Plasticity‐related genes (Prgs/PRGs) or lipid phosphate phosphatase‐
related proteins (LPPRs) comprise five known members, which have been linked to …