Systemic sclerosis (SSc), also referred to as systemic scleroderma or scleroderma, is a rare,
complex immune-mediated connective tissue disease characterized by progressive skin …

Systemic sclerosis (SSc) is an orphan disease characterised by autoimmunity, fibrosis of the
skin and internal organs, and vasculopathy. SSc may be associated with high morbidity and …

Health-related quality of life (HRQoL), though rarely considered as a primary endpoint in
clinical trials, may be the single outcome reflective of patient priorities when living with a …

Objective Systemic sclerosis (SSc) is an autoimmune disease with health-related quality of
life (HRQoL) high impairment. Pain is of paramount importance to be targeted by …

Systemic sclerosis (SSc), the most lethal of rheumatologic conditions, is the cause of death
in> 50% of SSc cases, led by pulmonary fibrosis followed by pulmonary hypertension and …

Abstract Background Systemic sclerosis (SSc) is a rare autoimmune disease characterized
by fibrosis of the skin and the involvement of multiple internal organs. Previous studies …

Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease whereby its
main pathological drivers of disability and damage are vascular injury, inflammatory cell …

Interstitial lung disease (ILD) is a common manifestation of systemic autoimmune diseases
and a leading cause of death in these patients. A proportion of patients with autoimmune …

Background Skin ulcers (SU) are one of the most frequent manifestations of systemic
sclerosis (SSc). SSc-SU are very painful, often persistent and recurrent; they may lead to …

Systemic sclerosis represents a chronic connective tissue disease featuring fibrosis,
vasculopathy and autoimmunity, affecting skin, multiple internal organs, and skeletal …