The mechanobiology of articular cartilage: bearing the burden of osteoarthritis

J Sanchez-Adams, HA Leddy, AL McNulty… - Current rheumatology …, 2014 - Springer
Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

Establishing outcome measures in early knee osteoarthritis

CA Emery, JL Whittaker, A Mahmoudian… - Nature Reviews …, 2019 - nature.com
The classification and monitoring of individuals with early knee osteoarthritis (OA) are
important considerations for the design and evaluation of therapeutic interventions and …

Joint distraction for osteoarthritis: clinical evidence and molecular mechanisms

MP Jansen, SC Mastbergen - Nature Reviews Rheumatology, 2022 - nature.com
Joint distraction, the prolonged mechanical separation of the bones at a joint, has emerged
as a joint-preserving treatment for end-stage osteoarthritis, with the gradually growing …

In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee

DD Chan, L Cai, KD Butz, SB Trippel, EA Nauman… - Scientific reports, 2016 - nature.com
The in vivo measurement of articular cartilage deformation is essential to understand how
mechanical forces distribute throughout the healthy tissue and change over time in the …

Cartilage biomechanics: From the basic facts to the challenges of tissue engineering

N Petitjean, P Canadas, P Royer… - … Research Part A, 2023 - Wiley Online Library
Articular cartilage (AC) is the thin tissue that covers the long bone ends in the joints and that
ensures the transmission of forces between adjacent bones while allowing nearly …

Influence of the mechanical environment on the regeneration of osteochondral defects

S Davis, M Roldo, G Blunn, G Tozzi… - … in Bioengineering and …, 2021 - frontiersin.org
Articular cartilage is a highly specialised connective tissue of diarthrodial joints which
provides a smooth, lubricated surface for joint articulation and plays a crucial role in the …

Three‐dimensional motion of the knee‐joint complex during normal walking revealed by mobile biplane x‐ray imaging

HA Gray, S Guan, LT Thomeer… - Journal of …, 2019 - Wiley Online Library
Accurate knowledge of knee kinematics is important for a better understanding of normal
joint function and for improving patient outcomes subsequent to joint reconstructive surgery …

Mechanical properties of normal and osteoarthritic human articular cartilage

DL Robinson, ME Kersh, NC Walsh, DC Ackland… - Journal of the …, 2016 - Elsevier
Isotropic hyperelastic models have been used to determine the material properties of normal
human cartilage, but there remains an incomplete understanding of how these properties …

Function of the medial meniscus in force transmission and stability

PS Walker, S Arno, C Bell, G Salvadore… - Journal of …, 2015 - Elsevier
We studied the combined role of the medial meniscus in distributing load and providing
stability. Ten normal knees were loaded in combinations of compressive and shear loading …

Diurnal variations in articular cartilage thickness and strain in the human knee

JL Coleman, MR Widmyer, HA Leddy, GM Utturkar… - Journal of …, 2013 - Elsevier
Due to the biphasic viscoelastic nature of cartilage, joint loading may result in deformations
that require times on the order of hours to fully recover. Thus, cartilaginous tissues may …