Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Bactericidal antibiotics induce toxic metabolic perturbations that lead to cellular damage

P Belenky, DY Jonathan, CBM Porter, NR Cohen… - Cell reports, 2015 - cell.com
Understanding how antibiotics impact bacterial metabolism may provide insight into their
mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we …

Herpes simplex virus 1-induced ferroptosis contributes to viral encephalitis

XQ Xu, T Xu, W Ji, C Wang, Y Ren, X Xiong, X Zhou… - Mbio, 2023 - Am Soc Microbiol
ABSTRACT Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family
Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous …

DNA Repair in Staphylococcus aureus

KP Ha, AM Edwards - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
Staphylococcus aureus is a common cause of both superficial and invasive infections of
humans and animals. Despite a potent host response and apparently appropriate antibiotic …

Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae

W Qiu, X Liu, F Yang, R Li, Y Xiong, C Fu, G Li… - Science of the total …, 2020 - Elsevier
In China, antibiotics are commonly used for human and veterinary medicine, and they are
present in various environmental media. Thus, the toxic effects of antibiotics on organisms …

[HTML][HTML] Exploring antimicrobial mechanism of essential oil of Amomum villosum Lour through metabolomics based on gas chromatography-mass spectrometry in …

C Tang, J Chen, Y Zhou, P Ding, G He, L Zhang… - Microbiological …, 2021 - Elsevier
Amomum villosum Lour (A. villosum Lour) has medicinal properties and has been widely
used in China for many years. Herein we aimed to investigate the antibacterial mechanism …

Cyclic AMP regulates bacterial persistence through repression of the oxidative stress response and SOS-dependent DNA repair in uropathogenic Escherichia coli

RC Molina-Quiroz, C Silva-Valenzuela, J Brewster… - MBio, 2018 - Am Soc Microbiol
Bacterial persistence is a transient, nonheritable physiological state that provides tolerance
to bactericidal antibiotics. The stringent response, toxin-antitoxin modules, and stochastic …

PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation

T Comyn, T Preat, A Pavlowsky, PY Plaçais - Elife, 2024 - elifesciences.org
Relevance-based selectivity and high energy cost are two distinct features of long-term
memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a …

Role of the stringent stress response in the antibiotic resistance phenotype of methicillin-resistant Staphylococcus aureus

S Aedo, A Tomasz - Antimicrobial agents and chemotherapy, 2016 - Am Soc Microbiol
Resistance to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus (MRSA)
requires the presence of an acquired genetic determinant, mecA or mecC, which encode …

Proteomic study of the survival and resuscitation mechanisms of filamentous persisters in an evolved Escherichia coli population from cyclic ampicillin treatment

JE Sulaiman, H Lam - Msystems, 2020 - Am Soc Microbiol
Through adaptive laboratory evolution (ALE) experiments, it was recently found that when a
bacterial population was repetitively treated with antibiotics, they will adapt to the treatment …