Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years

TL Verplaetse, KP Cosgrove, J Tanabe… - Journal of …, 2021 - Wiley Online Library
Over the last 10 years, rates of alcohol use disorder (AUD) have increased in women by
84% relative to a 35% increase in men. Rates of alcohol use and high‐risk drinking have …

A neural signature for the subjective experience of threat anticipation under uncertainty

X Liu, G Jiao, F Zhou, KM Kendrick, D Yao… - Nature …, 2024 - nature.com
Uncertainty about potential future threats and the associated anxious anticipation represents
a key feature of anxiety. However, the neural systems that underlie the subjective …

Stress allostasis in substance use disorders: promise, progress, and emerging priorities in clinical research

GE Fronk, SJ Sant'Ana, JT Kaye… - Annual review of clinical …, 2020 - annualreviews.org
Clinicians and researchers alike have long believed that stressors play a pivotal etiologic
role in risk, maintenance, and/or relapse of alcohol and other substance use disorders …

Acute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety

SM Gorka, KJ Khorrami, CA Manzler… - Translational Psychiatry, 2022 - nature.com
Research indicates that heightened anticipatory anxiety underlies several forms of
psychopathology. Anticipatory anxiety can be reliably and objectively measured in the …

Common and separable neural alterations in substance use disorders: A coordinate‐based meta‐analyses of functional neuroimaging studies in humans

B Klugah‐Brown, X Di, J Zweerings… - Human brain …, 2020 - Wiley Online Library
Delineating common and separable neural alterations in substance use disorders (SUD) is
imperative to understand the neurobiological basis of the addictive process and to inform …

High-risk drinkers engage distinct stress-predictive brain networks

EV Goldfarb, D Scheinost, N Fogelman, D Seo… - Biological psychiatry …, 2022 - Elsevier
Background Excessive alcohol intake is a major public health problem and can be triggered
by stress. Heavy drinking in patients with alcohol use disorder also alters neural …

Active inference, epistemic value, and uncertainty in conceptual disorganization in first-episode schizophrenia

R Limongi, AM Silva, M Mackinley, SD Ford… - Schizophrenia …, 2023 - academic.oup.com
Abstract Background and Hypothesis Active inference has become an influential concept in
psychopathology. We apply active inference to investigate conceptual disorganization in first …

Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth

SM Gorka, M Radoman, J Jimmy, KA Kreutzer… - …, 2023 - nature.com
Prior studies show that individuals with alcohol use disorder exhibit exaggerated behavioral
and brain reactivity to uncertain threats (U-threat). It is posited this brain-based factor …

A rare scare: The role of intolerance of uncertainty in startle responses and event-related potentials in anticipation of unpredictable threat

HP Carsten, K Härpfer, A Riesel - International Journal of …, 2022 - Elsevier
Intolerance of uncertainty (IU) represents a transdiagnostic risk factor for internalizing
psychopathology. However, little is known regarding its psychophysiological correlates. IU is …

Bed nucleus of the stria terminalis network responses to unpredictable threat in early alcohol abstinence

NL Zabik, EA Flook, B Feola… - Alcohol: Clinical and …, 2024 - Wiley Online Library
Background Anxiety during early alcohol abstinence, likely resulting from neural changes
caused by chronic alcohol use, contributes to high relapse rates. Studies in rodents show …