Keratoconus

RB Singh, S Koh, N Sharma, FA Woreta… - Nature Reviews …, 2024 - nature.com
Keratoconus is a progressive eye disorder primarily affecting individuals in adolescence and
early adulthood. The ectatic changes in the cornea cause thinning and cone-like steepening …

Management of keratoconus: an updated review

R Deshmukh, ZZ Ong, R Rampat… - Frontiers in …, 2023 - frontiersin.org
Keratoconus is the most common corneal ectatic disorder. It is characterized by progressive
corneal thinning with resultant irregular astigmatism and myopia. Its prevalence has been …

Corneal epithelial stem cells–physiology, pathophysiology and therapeutic options

Y Ruan, S Jiang, A Musayeva, N Pfeiffer, A Gericke - Cells, 2021 - mdpi.com
In the human cornea, regeneration of the epithelium is regulated by the stem cell reservoir of
the limbus, which is the marginal region of the cornea representing the anatomical and …

Corneal transplantation after failed grafts: Options and outcomes

JLA Del Barrio, M Bhogal, M Ang, M Ziaei… - Survey of …, 2021 - Elsevier
Corneal transplantation is the most commonly performed human tissue transplantation
procedure worldwide. Because of the large number of transplants, corneal graft failure has …

Causes of corneal transplant failure: a multicentric study

A Gómez‐Benlloch, A Montesel… - Acta …, 2021 - Wiley Online Library
Purpose To identify the causes of failure of the different surgical corneal graft techniques:
penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet …

Current perspectives on corneal transplantation

S Liu, YL Wong, A Walkden - Clinical Ophthalmology, 2022 - Taylor & Francis
Disease of the cornea is the third leading cause of blindness worldwide. Corneal graft
surgery is one of the most successful forms of solid organ transplantations in humans, with …

Artificial intelligence in corneal diseases: A narrative review

T Nguyen, J Ong, M Masalkhi, E Waisberg… - Contact Lens and …, 2024 - Elsevier
Corneal diseases represent a growing public health burden, especially in resource-limited
settings lacking access to specialized eye care. Artificial intelligence (AI) offers promising …

The landscape of clinical trials in corneal regeneration: A systematic review of tissue engineering approaches in corneal disease

S Boroumand, M Rahmani, F Sigaroodi… - … Research Part B …, 2024 - Wiley Online Library
The limited availability of a healthy donor cornea and the incidence of allograft failure led
researchers to seek other corneal substitutes via tissue engineering. Exploring the trend of …

An inspired microenvironment of cell replicas to induce stem cells into keratocyte-like dendritic cells for corneal regeneration

M Fallah Tafti, H Aghamollaei… - Scientific Reports, 2023 - nature.com
Corneal stromal disorders due to the loss of keratocytes can affect visual impairment and
blindness. Corneal cell therapy is a promising therapeutic strategy for healing corneal tissue …

Corneal stroma regeneration: Preclinical studies

JLA Del Barrio, F Arnalich-Montiel… - Experimental Eye …, 2021 - Elsevier
Corneal grafting is one of the most common and successful forms of human tissue
transplantation in the world, but the need for corneal grafting is growing and availability of …