Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that
has been thoroughly revised. Don and Judy Voet explain biochemical concepts while …

New well-designed materials are highly demanded with the prospect of versatile properties,
offering successful applications as alternates to conventional materials. Major new insights …

Tethering factors have been shown to interact with Rabs and SNAREs and, more recently,
with coat proteins. Coat proteins are required for cargo selection and membrane …

A substantial fraction of eukaryotic gene products are synthesized by ribosomes attached at
the cytosolic face of the endoplasmic reticulum (ER) membrane. These polypeptides enter …

Eukaryotic cells are able to discriminate between native and non‐native polypeptides,
selectively transporting the former to their final destinations. Secretory proteins are …

Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells …

The pathways that distinguish transport of folded and misfolded cargo through the exocytic
(secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global …

As proteins travel through the endoplasmic reticulum (ER), a quality-control system retains
newly synthesized polypeptides and supports their maturation. Only properly folded proteins …