In-cell NMR: Why and how?

FX Theillet, E Luchinat - Progress in Nuclear Magnetic Resonance …, 2022 - Elsevier
NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

Recent advances in the application of parahydrogen in catalysis and biochemistry

G Buntkowsky, F Theiss, J Lins, YA Miloslavina… - RSC …, 2022 - pubs.rsc.org
Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI)
are analytical and diagnostic tools that are essential for a very broad field of applications …

Hyperpolarized Carbon-13 MRI in Breast Cancer

R Woitek, KM Brindle - Diagnostics, 2023 - mdpi.com
One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic
glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR …

Conversion of Hyperpolarized [1-13C]Pyruvate in Breast Cancer Cells Depends on Their Malignancy, Metabolic Program and Nutrient Microenvironment

M Grashei, P Biechl, F Schilling, AM Otto - Cancers, 2022 - mdpi.com
Simple Summary The metabolic phenotype of cancer cells depends on their metabolic
program and the availability of nutrients in the tumor microenvironment. Metabolic activities …

Metabolic alterations in acute myocardial ischemia-reperfusion injury and necrosis using in vivo hyperpolarized [1-13C] pyruvate MR spectroscopy

CM Moon, YH Kim, YK Ahn, MH Jeong, GW Jeong - Scientific Reports, 2019 - nature.com
This study aimed to investigate real-time early detection of metabolic alteration in a rat
model with acute myocardial ischemia-reperfusion (AMI/R) injury and myocardial necrosis …

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice …

R Sriram, M Van Criekinge, J DeLos Santos, F Ahamed… - Cancers, 2020 - mdpi.com
Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is
needed for men with localized disease. Hyperpolarized (HP) 13C magnetic resonance (MR) …

[HTML][HTML] Hyperpolarized magnetic resonance and artificial intelligence: Frontiers of imaging in pancreatic cancer

JS Enriquez, Y Chu, S Pudakalakatti… - JMIR Medical …, 2021 - medinform.jmir.org
Background: There is an unmet need for noninvasive imaging markers that can help identify
the aggressive subtype (s) of pancreatic ductal adenocarcinoma (PDAC) at diagnosis and at …

Cancer metabolism in a snapshot: MRS (I)

M Julià‐Sapé, AP Candiota, C Arús - NMR in Biomedicine, 2019 - Wiley Online Library
The contribution of MRS (I) to the in vivo evaluation of cancer‐metabolism‐derived metrics,
mostly since 2016, is reviewed here. Increased carbon consumption by tumour cells, which …

[HTML][HTML] Updated developments on molecular imaging and therapeutic strategies directed against necrosis

D Zhang, M Gao, Q Jin, Y Ni, J Zhang - Acta Pharmaceutica Sinica B, 2019 - Elsevier
Cell death plays important roles in living organisms and is a hallmark of numerous disorders
such as cardiovascular diseases, sepsis and acute pancreatitis. Moreover, cell death also …

Optimizing the reaction conditions for the formation of fumarate via trans-hydrogenation

L Wienands, F Theiß, J Eills, L Rösler, S Knecht… - Applied Magnetic …, 2022 - Springer
Parahydrogen-induced polarization is a hyperpolarization method for enhancing nuclear
magnetic resonance signals by chemical reactions/interactions involving the para spin …