Metastatic cancer remains an incurable disease in the majority of cases and thus novel
treatment strategies such as oncolytic virotherapy are rapidly advancing toward clinical use …

Imaging of T-cells and their responses during anti-cancer immunotherapy - PMC Back to Top
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Chimeric antigen receptor T cell therapy (CAR-T) has been rolled out as a new treatment for
hematological malignancies. For solid tumor treatment, CAR-T has been disappointing so …

The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal
and mammary iodide uptake. It was first cloned from the rat in 1996 and shortly thereafter …

Cell therapies represent a rapidly emerging class of new therapeutics. They are intended
and developed for the treatment of some of the most prevalent human diseases, including …

Preclinical and clinical tomographic imaging systems increasingly are being utilized for non-
invasive imaging of reporter gene products to reveal the distribution of molecular …

Imaging modalities such as micro‐computed tomography (micro‐CT), micro‐positron
emission tomography (micro‐PET), high‐resolution MRI, optical imaging, and high …

Due to its dual role as reporter and therapy gene, the sodium iodide symporter (NIS) allows
noninvasive imaging of functional NIS expression by 123 I-scintigraphy or 124 I-PET …

Molecular cloning of the NIS gene in 1996 allowed examination of the molecular basis of
congenital hypothyroidism due to iodide transport defect (ITD) many years after the first case …

Introduction: Oncolytic viruses are experimental cancer therapies being translated to the
clinic. They are unique in their ability to amplify within the body, therefore requiring careful …