Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Sawdust materials are global wastes obtained from wood processing and exploitation
activities. They are usually dumped/stored in uncontrolled conditions, thus becoming a …

Introducción: el cáncer de pulmón es un problema de Salud Pública en el mundo y en
nuestro país por su alta mortalidad e incidencia. Los carcinógenos medioambientales y el …

Many substances are already tested in the long-term rodent bioassay (RCB). Nonetheless,
statements such as the following are common in the regulatory literature:“the significance of …

Background The high toxicity of hexavalent chromium [Cr (VI)] could not only cause harmful
effects on humans, including carcinogenicity, respiratory issues, genetic damage, and skin …

Carcinogenicity of hexavalent chromium [Cr (VI)] has been supported by a number of
epidemiological and animal studies; however, its carcinogenic mode of action is still …

Cancer is a multifaceted disease influenced by genetic mutations and environmental factors,
including exposure to carcinogens. This review presents an in-depth analysis of the …

The nonclinical branch of regulatory pharmacology has traditionally relied on the sensitivity
and specificity of regulatorily recommended bioassays. Nonetheless, any predictive testing …

Regarding carcinogenicity testing, the long‐term rodent bioassay (RCB) has been the test
required by most regulatory agencies across the world. Nonetheless, due to the lack of …

For a significant share of the chemicals, current bioassays mispredicted the outcomes in the
reference methods they simulate. For any drug or chemical, and depending on the …