Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

One of the central questions in neuroscience is how particular tasks, or computations, are
implemented by neural networks to generate behavior. The prevailing view has been that …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …

Basal dendrites receive the majority of synapses that contact neocortical pyramidal neurons,
yet our knowledge of synaptic processing in these dendrites has been hampered by their …

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied
neuron types in the mammalian neocortex and has become a benchmark for understanding …

Persistent neural activity refers to a sustained change in action potential discharge that long
outlasts a stimulus. It is found in a diverse set of brain regions and organisms and several in …

Glutamate is the most abundant neurotransmitter of the central nervous system, as the
majority of neurons use glutamate as neurotransmitter. It is also well known that this …

In the field of cortical cellular physiology, much effort has been invested in understanding
thick apical dendrites of pyramidal neurons and the regenerative sodium and calcium spikes …

Focal activation of glutamate receptors in distal dendrites of hippocampal pyramidal cells
triggers voltage-dependent Ca 2+ channel-mediated plateau potentials that are confined to …