Drug resistance in Giardia duodenalis

BRE Ansell, MJ McConville, SY Ma'ayeh… - Biotechnology …, 2015 - Elsevier
Giardia duodenalis is a microaerophilic parasite of the human gastrointestinal tract and a
major contributor to diarrheal and post-infectious chronic gastrointestinal disease world …

Low-molecular-mass antioxidants in parasites

RL Krauth-Siegel, AE Leroux - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …

Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome

CA Gilchrist, E Houpt, N Trapaidze, Z Fei… - Molecular and …, 2006 - Elsevier
A genome-wide transcriptional analysis of Entamoeba histolytica was performed on
trophozoites isolated from the colon of six infected mice and from in vitro culture. An …

[HTML][HTML] Entamoeba thiol-based redox metabolism: A potential target for drug development

G Jeelani, T Nozaki - Molecular and biochemical parasitology, 2016 - Elsevier
Amebiasis is an intestinal infection widespread throughout the world caused by the human
pathogen Entamoeba histolytica. Metronidazole has been a drug of choice against …

Stress Exacerbates Infectivity and Pathogenicity of Blastocystis hominis: In Vitro and In Vivo Evidences

S Chandramathi, K Suresh, S Sivanandam… - PloS one, 2014 - journals.plos.org
Background Stress alters the oxidant-antioxidant state and immune cell responses which
disrupts its function to combat infection. Blastocystis hominis, a common intestinal protozoan …

Escherichia coli mediated resistance of Entamoeba histolytica to oxidative stress is triggered by oxaloacetate

Y Shaulov, C Shimokawa, M Trebicz-Geffen… - PLoS …, 2018 - journals.plos.org
Amebiasis, a global intestinal parasitic disease, is due to Entamoeba histolytica. This
parasite, which feeds on bacteria in the large intestine of its human host, can trigger a strong …

Entamoeba histolytica—Gut Microbiota Interaction: More Than Meets the Eye

S Ankri - Microorganisms, 2021 - mdpi.com
Amebiasis is a disease caused by the unicellular parasite Entamoeba histolytica. In most
cases, the infection is asymptomatic but when symptomatic, the infection can cause …

Differential gene expression in Giardia lamblia under oxidative stress: significance in eukaryotic evolution

D Raj, E Ghosh, AK Mukherjee, T Nozaki, S Ganguly - Gene, 2014 - Elsevier
Giardia lamblia is a unicellular, early branching eukaryote causing giardiasis, one of the
most common human enteric diseases. Giardia, a microaerophilic protozoan parasite has to …

Comparison of cysteine content in whole proteomes across the three domains of life

A Castillo-Villanueva, H Reyes-Vivas… - Plos one, 2023 - journals.plos.org
An empirical observation suggests that Giardia lamblia proteins have larger cysteine content
than their counterparts in other organisms. As this parasite lacks conventional antioxidant …

Proteomic Identification of Oxidized Proteins in Entamoeba histolytica by Resin-Assisted Capture: Insights into the Role of Arginase in Resistance to Oxidative Stress

P Shahi, M Trebicz-Geffen, S Nagaraja… - PLoS neglected …, 2016 - journals.plos.org
Entamoeba histolytica is an obligate protozoan parasite of humans, and amebiasis, an
infectious disease which targets the intestine and/or liver, is the second most common cause …