Apoptosis is an evolutionarily conserved and tightly regulated cell death modality. It serves
important roles in physiology by sculpting complex tissues during embryogenesis and by …

Alterations of cell death pathways, including apoptosis and the neutrophil specific kind of
death called NETosis, can represent a potential source of autoantigens. Defects in the …

The release of extracellular vesicles (EV) by the syncytiotrophoblast (STB) may be an
important mechanism by which the placenta signals to the mother. STB derived EV (STBEV) …

Neutrophils recognize particulate substrates of microbial or endogenous origin and react by
sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps …

Apoptosis happens continuously for millions of cells along with the active removal of
apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, ie, the …

Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease of
unknown etiology that mainly affects women in the childbearing age. SLE is a prototype type …

Systemic lupus erythematosus (SLE) is a systemic and poly-aetiological autoimmune
disease characterized by the production of antibodies to autologous double-stranded DNA …

The immune system struggles every day between responding to foreign antigens and
tolerating self-antigens to delicately maintain tissue homeostasis. If self-tolerance is broken …

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that
protein interactions act as sophisticated data processing networks that govern intracellular …

As a heterogeneous autoimmune disease associated with severe organ damage, the
precise mechanisms of systemic lupus erythematosus (SLE) remain to be clarified. Recent …