Myofibroblast-mediated mechanisms of pathological remodelling of the heart

KT Weber, Y Sun, SK Bhattacharya… - Nature Reviews …, 2013 - nature.com
The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

[PDF][PDF] Local bone marrow renin-angiotensin system in the genesis of leukemia and other malignancies.

IC Haznedaroglu, UY Malkan - European Review for Medical & …, 2016 - europeanreview.org
The existence of a local renin-an-giotensin system (RAS) specific to the hematopoietic bone
marrow (BM) microenvironment had been proposed two decades ago. Most of the RAS …

Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues

VJ Jokubaitis, L Sinka, R Driessen… - Blood, The Journal …, 2008 - ashpublications.org
Previous studies revealed that mAb BB9 reacts with a subset of CD34+ human BM cells with
hematopoietic stem cell (HSC) characteristics. Here we map BB9 expression throughout …

[HTML][HTML] Pharmacologic ACE-inhibition mitigates radiation-induced pneumonitis by suppressing ACE-expressing lung myeloid cells

GP Sharma, BL Fish, AC Frei, J Narayanan… - International Journal of …, 2022 - Elsevier
Purpose Radiation-induced lung injury is a major dose-limiting toxicity for thoracic radiation
therapy patients. In experimental models, treatment with angiotensin converting enzyme …

[PDF][PDF] Angiotensin converting enzymes ACE and ACE2 in thyroid cancer progression.

SS Narayan, K Lorenz, J Ukkat, C Hoang-Vu… - Thyroid, 2020 - researchgate.net
Running title: ACEs in thyroid cancer Angiotensin converting enzymes ACE and ACE2 in
thyroid cancer progression. SS NARAYAN1, Page 1 1 NEOPLASMA accepted, non-corrected …

Renin angiotensin system genes are biomarkers for personalized treatment of acute myeloid leukemia with Doxorubicin as well as etoposide

S Turk, C Turk, MW Akbar, B Kucukkaraduman… - PLoS …, 2020 - journals.plos.org
Despite the availability of various treatment protocols, response to therapy in patients with
Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling …

[HTML][HTML] Angiotensin-converting enzyme is required for normal myelopoiesis

C Lin, V Datta, D Okwan-Duodu, X Chen… - The FASEB …, 2011 - ncbi.nlm.nih.gov
Inhibition of angiotensin-converting enzyme (ACE) induces anemia in humans and mice, but
it is unclear whether ACE is involved in other aspects of hematopoiesis. Here, we …

[HTML][HTML] The contribution of the AT1 receptor to erythropoiesis

AF Rodrigues, M Bader - Biochemical Pharmacology, 2023 - Elsevier
The renin-angiotensin system (RAS) comprises a broad set of functional peptides and
receptors that play a role in cardiovascular homeostasis and contribute to cardiovascular …

Local bone marrow renin–angiotensin system in primitive, definitive and neoplastic haematopoiesis

IC Haznedaroglu, Y Beyazit - Clinical science, 2013 - portlandpress.com
The locally active ligand peptides, mediators, receptors and signalling pathways of the
haematopoietic BM (bone marrow) autocrine/paracrine RAS (renin–angiotensin system) …

Pathobiological aspects of the local bone marrow renin-angiotensin system: a review

IC Haznedaroglu, Y Beyazit - Journal of the Renin …, 2010 - journals.sagepub.com
The local haematopoietic bone marrow (BM) renin—angiotensin system (RAS) mediates
pathobiological alterations of haematopoiesis in an autocrine/paracrine/intracrine fashion …