Advances in innate immunity over the past decade have revealed distinct classes of pattern
recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular …

It is becoming clear that the manner by which the immune response resolves or contains
infection by a pathogen varies according to the tissue that is affected. Unlike many …

A conserved herpesviral kinase, designated ORF36 in murine γ-herpesvirus 68 (MHV-68),
plays multiple vital roles in the viral life cycle. Here, we show by screening mutant viruses …

Alpha/beta interferon (IFN-α/β) protects the host from virus infection by inhibition of lytic virus
replication in infected cells and modulation of the antiviral cell-mediated immune response …

Murine norovirus (MNV) was recently discovered in Rag2−/−/Stat1−/− mice in a US medical
research facility. Presently, little is known concerning the epidemiology and natural history of …

Host genes that regulate systemic inflammation upon chronic viral infection are incompletely
understood. Murine gammaherpesvirus 68 (MHV68) infection is characterized by latency in …

Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are
significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus …

Учитывая бурный прогресс фундаментальных и прикладных исследований по вирусам
и вирусным болезням, назрела необходимость настоящего издания. Руководство …

ABSTRACT CD8+ T cell responses are critical to the control of replication and reactivation
associated with gammaherpesvirus infection. Type I interferons (IFNs) have been shown to …

Viral infectious diseases are a significant burden on public health and the global economy,
and new viral threats emerge continuously. Since CD4+ and CD8+ T cell responses are …