Axon Initial Segment Structure and Function in Health and Disease

PM Jenkins, KJ Bender - Physiological Reviews, 2024 - journals.physiology.org
At the simplest level, neurons are structured to integrate synaptic input and perform
computational transforms on that input, converting it into an action potential (AP) code. This …

Contribution of axon initial segment structure and channels to brain pathology

JJ Garrido - Cells, 2023 - mdpi.com
Brain channelopathies are a group of neurological disorders that result from genetic
mutations affecting ion channels in the brain. Ion channels are specialized proteins that play …

Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity

C Lefebvre-Omar, E Liu, C Dalle, BL d'Incamps… - Cellular and Molecular …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …

RNA-binding proteins as a common ground for neurodegeneration and inflammation in amyotrophic lateral sclerosis and multiple sclerosis

I Acosta-Galeana, R Hernández-Martínez… - Frontiers in Molecular …, 2023 - frontiersin.org
The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and
multiple sclerosis were once thought to be completely distinct entities that did not share any …

Role of Abl1 Kinase in Axon Initial Segment Disassembly and its Consequences on Axonal Trafficking in Alzheimer's Disease

NGS Castillo - 2024 - search.proquest.com
El desensamble del segmento inicial del axón ha comenzado recientemente a ser
apreciado como un evento importante en la patología de la enfermedad de Alzheimer, ya …

[PDF][PDF] Isabel Acosta-Galeana, Ricardo Hernández-Martínez 2, Tania Reyes-Cruz 3, Erwin Chiquete 4 and Jose de Jesus Aceves-Buendia 4

I Acosta-Galeana - 2023 - researchgate.net
Neurodegenerative diseases can affect the nervous system in a wide range of manners,
affecting cognition in the case of frontotemporal dementia (FTD) to independent movement …

Contribution of Axon Initial Segment Structure and Channels to Brain Pathology

JJ Garrido Jurado - 2023 - digital.csic.es
Brain channelopathies are a group of neurological disorders that result from genetic
mutations affecting ion channels in the brain. Ion channels are specialized proteins that play …

Multiphoton Imaging Reveals Regional and Activity-Dependent Regulation of Oligodendrocyte Lineage Cell Dynamics

MA Thornton - 2023 - search.proquest.com
Oligodendrocytes in the central nervous system enwrap axons with myelin, the dynamic
multilayer plasma membrane structure that regulates conduction velocity and provides …