The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

Traumatic brain injury (TBI) represents a major cause of death and disability in developed
countries. Brain injuries are highly heterogeneous and can also trigger other neurological …

Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

The blood-brain barrier (BBB) is a dynamic interface between the peripheral blood supply
and the cerebral parenchyma, controlling the transport of material to and from the brain …

Background The use of blood biomarkers after mild traumatic brain injury (mTBI) has been
widely studied. We have identified eight unresolved issues related to the use of five …

The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

Traumatic brain injury (TBI) is the leading cause of death in young adults and children. The
treatment of TBI in the acute phase has improved substantially; however, the prevention and …

Traumatic brain injury (TBI) is a risk factor for dementia. Mixed neurodegenerative
pathologies have been described in late survivors of TBI, but the mechanisms driving post …