mRNA-based vaccines and therapeutics for COVID-19 and future pandemics
An unheard mobilization of resources to find SARS-CoV-2 vaccines and therapies has been
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …
sparked by the COVID-19 pandemic. Two years ago, COVID-19's launch propelled mRNA …
[HTML][HTML] A systematic review of autopsy findings in deaths after COVID-19 vaccination
N Hulscher, PE Alexander, R Amerling… - Forensic Science …, 2024 - Elsevier
Background The rapid development of COVID-19 vaccines, combined with a high number of
adverse event reports, have led to concerns over possible mechanisms of injury including …
adverse event reports, have led to concerns over possible mechanisms of injury including …
[HTML][HTML] Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency
The use of modified nucleotides to suppress the interferon response and maintain
translation of self-amplifying RNA (saRNA), which has been achieved for mRNA, has not yet …
translation of self-amplifying RNA (saRNA), which has been achieved for mRNA, has not yet …
[HTML][HTML] Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity
Lipid nanoparticles (LNPs) can be designed to potentiate cancer immunotherapy by
promoting their uptake by antigen-presenting cells, stimulating the maturation of these cells …
promoting their uptake by antigen-presenting cells, stimulating the maturation of these cells …
mRNA-based vaccine for COVID-19: they are new but not unknown!
mRNA vaccines take advantage of the mechanism that our cells use to produce proteins.
Our cells produce proteins based on the knowledge contained in our DNA; each gene …
Our cells produce proteins based on the knowledge contained in our DNA; each gene …
Understanding the pharmacology of COVID-19 mRNA vaccines: playing dice with the spike?
M Cosentino, F Marino - International journal of molecular sciences, 2022 - mdpi.com
Coronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination
campaigns in most Western countries. However, the emergency conditions in which their …
campaigns in most Western countries. However, the emergency conditions in which their …
SARS-CoV-2 and the spike protein in endotheliopathy
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …
compartment in the upper and lower airways. There is evidence that the microvasculature in …
[HTML][HTML] SARS-CoV-2 spike protein induces hemagglutination: implications for COVID-19 morbidities and therapeutics and for vaccine adverse effects
C Boschi, DE Scheim, A Bancod, M Militello… - International Journal of …, 2022 - mdpi.com
Experimental findings for SARS-CoV-2 related to the glycan biochemistry of coronaviruses
indicate that attachments from spike protein to glycoconjugates on the surfaces of red blood …
indicate that attachments from spike protein to glycoconjugates on the surfaces of red blood …
Immune response and molecular mechanisms of cardiovascular adverse effects of spike proteins from SARS-CoV-2 and mRNA vaccines
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the
COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells …
COVID-19 disease) uses the Spike proteins of its envelope for infecting target cells …
Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis
N Hulscher, R Hodkinson, W Makis… - ESC heart …, 2024 - Wiley Online Library
COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be
fatal. This systematic review aims to investigate potential causal links between COVID‐19 …
fatal. This systematic review aims to investigate potential causal links between COVID‐19 …