OX40 (CD134) is a tumor necrosis factor (TNF) receptor expressed primarily on activated
CD4+ and CD8+ T cells and transmits a potent costimulatory signal when engaged. OX40 is …

The cause of multiple sclerosis (MS) is unknown, but the pathology is consistent with an
immunological etiology. Studies conducted with the animal model of MS, experimental …

To elucidate the role of NK cells and TCRγ δ+ T cells in acute experimental autoimmune
encephalomyelitis (EAE) induced in Lewis rats, the distribution, number and function of …

Abstract OX40 (CD134), a membrane-bound member of the tumor-necrosis-factor-receptor
superfamily, is expressed primarily on activated CD4+ T cells. Recently, several groups …

In systemic lupus erythematosus, CD4+ T cells play key roles in the initiation and promotion
of autoantigen-specific humoral immunity, and indirect evidence suggests that T cells are …

The etiology of multiple sclerosis is linked to a variety of genetic and environmental factors.
Both cell-mediated and humoral immune responses, triggered by extraneous or …

To characterize the phenotype of inflammatory cells in the central nervous system (CNS) in
experimental autoimmune encephalomyelitis (EAE), Lewis rats were immunized with guinea …

Autoimmune diseases result from the activation of self-reactive T cells recognizing
autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to …

Background Several groups have Observl'CI two distinct yet related phenomena occurring at
the level of the individual patient or rodent strain: restricted V-gene usage and …

We have examined the functional consequences induced by interaction of DR2a‐restricted
myelin basic protein (MBP)(87–99)‐specific T cell clones (TCC) with altered peptide ligands …