Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

The removal of non‐coding sequences, introns, from the mRNA precursors is an essential
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …

Sequence logos are visually compelling ways of illustrating the biological properties of DNA,
RNA and protein sequences, yet it is currently difficult to generate and customize such logos …

In the malaria parasite Plasmodium falciparum, the switch from asexual multiplication to
sexual differentiation into gametocytes is essential for transmission to mosquitos. The …

Commitment to and completion of sexual development are essential for malaria parasites
(protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular …

Methods for visualizing protein or nucleic acid motifs have traditionally relied upon residue
frequencies to graphically scale character heights. We describe the pLogo, a motif …

Seq2Logo is a web-based sequence logo generator. Sequence logos are a graphical
representation of the information content stored in a multiple sequence alignment (MSA) and …

Complex organisms require tissue-specific transcriptional programs, yet little is known about
how these are established. The transcription factor FoxA1 is thought to contribute to gene …

Chloroplasts of photosynthetic organisms harness light energy and convert it into chemical
energy. In several land plants, GOLDEN2-LIKE (GLK) transcription factors are required for …

Insulator elements affect gene expression by preventing the spread of heterochromatin and
restricting transcriptional enhancers from activation of unrelated promoters. In vertebrates …