It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Pluripotent stem cells can be derived from embryos or induced from adult cells by
reprogramming. They are unique among stem cells in that they can give rise to all cell types …

The regulation of transcription requires the coordination of numerous activities on DNA, yet
how transcription factors mediate these activities remains poorly understood. Here, we use …

Fluorescent proteins (FP) are frequently used for studying proteins inside cells. In advanced
fluorescence microscopy, FPs can report on additional intracellular variables. One variable …

Forces generated by the cytoskeleton can be transmitted to the nucleus and chromatin via
physical links on the nuclear envelope and the lamin meshwork. Although the role of these …

The shape and differentiated state of many cell types are highly sensitive to the rigidity of the
microenvironment. The physical mechanisms involved, however, are unknown. Here, we …

The nucleus is sculpted toward various morphologies during cellular differentiation and
development. Alterations in nuclear shape often result in changes to chromatin organization …