[HTML][HTML] Translational advances of melanocortin drugs: Integrating biology, chemistry and genetics

T Montero-Melendez, T Boesen, TEN Jonassen - Seminars in Immunology, 2022 - Elsevier
Melanocortin receptors have emerged as important targets with a very unusual versatility, as
their widespread distribution on multiple tissues (eg skin, adrenal glands, brain, immune …

MC4R in Central and Peripheral systems

R Wei, D Li, S Jia, Y Chen, J Wang - Advanced Biology, 2023 - Wiley Online Library
Obesity has emerged as a critical and urgent health burden during the current global
pandemic. Among multiple genetic causes, melanocortin receptor‐4 (MC4R), involved in …

The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling

A Jamaluddin, RA Wyatt, J Lee, G Dowsett, JA Tadross… - bioRxiv, 2024 - biorxiv.org
The central melanocortin system links nutrition to energy expenditure, with melanocortin-4
receptor (MC4R) controlling appetite and food intake, and MC3R regulating timing of sexual …

Pharmacological regulation of melanocortin-3 and-4 receptors by melanocortin-2 receptor accessory protein 1 or 2

RL Ji Jr - 2022 - search.proquest.com
The neural melanocortin receptors (MCRs), melanocortin-3 and-4 receptors (MC3R and
MC4R), play essential non-redundant roles in the regulation of energy homeostasis …