Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance—A review

RK Saini, YS Keum - Life sciences, 2018 - Elsevier
Abstract Linoleic acid (LA)(n− 6) and α-linolenic acid (ALA)(n− 3) are essential fatty acids
(EFAs) as they cannot be synthesized by humans or other higher animals. In the human …

ω-3 and ω-6 polyunsaturated fatty acids, obesity and cancer

S D'Angelo, ML Motti, R Meccariello - Nutrients, 2020 - mdpi.com
Recently, nutraceutical bioactive compounds in foods have been discovered for their
potential health benefits regarding the prevention of chronic disorders, such as cancer, and …

Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications

I Khan, M Hussain, B Jiang, L Zheng, Y Pan, J Hu… - Progress in lipid …, 2023 - Elsevier
Abstract Recently, omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have
gained substantial interest due to their specific structure and biological functions. Humans …

[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs

M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …

Omega-3 fatty acids and cancer cell cytotoxicity: implications for multi-targeted cancer therapy

D D'Eliseo, F Velotti - Journal of clinical medicine, 2016 - mdpi.com
Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

AJ Cockbain, GJ Toogood, MA Hull - Gut, 2012 - gut.bmj.com
Omega (ω)-3 polyunsaturated fatty acids (PUFAs) are naturally occurring substances that
are well tolerated and have been used extensively for the prevention of cardiovascular …

Synthesis and significance of arachidonic acid, a substrate for cyclooxygenases, lipoxygenases, and cytochrome P450 pathways in the tumorigenesis of glioblastoma …

J Korbecki, E Rębacz-Maron, P Kupnicka, D Chlubek… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma multiforme is a brain tumor with a very unfavorable
prognosis, where the vast majority of patients do not survive a year after diagnosis. One line …

Omega-3 polyunsaturated fatty acids as adjuvant therapy of colorectal cancer

M Volpato, MA Hull - Cancer and Metastasis Reviews, 2018 - Springer
The majority of evidence linking anti-colorectal cancer (CRC) activity with omega-3
polyunsaturated fatty acids (O3FAs) has focussed on decreased CRC risk (prevention) …

ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

W Wang, J Zhu, F Lyu, D Panigrahy, KW Ferrara… - Prostaglandins & other …, 2014 - Elsevier
Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs;
however, the results from human trials are mixed, making it difficult to provide dietary …

Dietary modulation of oxylipins in cardiovascular disease and aging

SPB Caligiuri, M Parikh… - American Journal …, 2017 - journals.physiology.org
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …